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Clinical and experimental evidence

Explore the Fundación Instituto Nacional de Heridas clinical study and five MedETechni Journal articles. Findings, methods and original publications in one place.

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Clinical research · ChileFINH / 2025

Virgilio Rays, in clinical practice.

Fundación Instituto Nacional de Heridas

15-day follow-upCase series
99%

Initial bacterial reduction

Mean of patient reductions · table 3

88%

Bacterial reduction at day 15

Relative to baseline · post-application

46%

Mean wound-area reduction

At 15 days · article abstract

Revista Latinoamericana de Enfermeras en Heridas y Ostomías
Vol. 6 · November 2025 · pp. 71–82

Read the INH publication
Study design and interpretation

Prospective uncontrolled series of 5 patients: 3 venous and 2 diabetic foot ulcers, with advanced wound care. Bacterial percentages average individual changes. The abstract reports 46% for area; the body, 48% (6.88 to 3.67 cm²). Findings describe this series and do not estimate a causal effect.

Aburto I; Alburquenque C; Espinoza G. Short-wavelength ultraviolet radiation in diabetic foot and venous ulcers with prolonged inflammation. 2025.

Articles and findings

MedETechni Journal · Volume 1 · 2026

5 articles displayed

Human and environmental evidencee0001 · Vol. 1 · 2026

Efficacy and safety of 222-nm far-UVC radiation in humans and occupied spaces: a systematic review

Systematic review

Kevin Virgilio Morales Chamorro; Gricell Jeraldina Báez Arévalo.

17 + 13human reports + environmental reports
Explore methods and scope

Methods

Retrospective systematic review of human and environmental evidence, without meta-analysis.

Scope and limitations

Findings apply to the exposures and study designs examined. They do not establish causal prevention of infections or universal or long-term safety.

Published findings

Included 17 human and 13 environmental reports. In one wound trial, the adjusted day-15 interaction favored wound status (PSST: β −4.79 points; 95% CI −7.29 to −2.29) and bioburden. The effect on wound area was uncertain (β −11.06 cm²; 95% CI −22.19 to 0.07). Some ocular regimens produced discomfort and superficial findings.

Microbial inactivatione0002 · Vol. 1 · 2026

Microbial inactivation by 222-nm far-UVC: a systematic review and dose-response synthesis in air, water, surfaces and biofilms

Systematic review and dose-response synthesis

Kevin Virgilio Morales Chamorro; Gricell Jeraldina Báez Arévalo.

51D90 conditions analyzed
Explore methods and scope

Methods

Retrospective systematic review of a selected corpus, with evidence mapping and dose-response synthesis.

Scope and limitations

D90 denotes the exposure required for a 90% microbial reduction under the model. Comparisons are matrix- and model-specific; no stratum met the meta-analysis criterion, and no universal dose or clinical efficacy was established.

Published findings

The integrated map contained 103 reports and 63 inclusions. The synthesis covered 51 D90 conditions from six reports. Preserving the complete curve changed D90 in one McDonald model from 1.86 to 8.30 mJ/cm²; four Petersen D90 targets remained unattainable under the fitted plateaus.

Dosimetric reporting and traceabilitye0003 · Vol. 1 · 2026

Reporting quality and metrological traceability of 222-nm far-UVC dosimetry: a systematic review and metascientific audit

Systematic review and metascientific audit

Kevin Virgilio Morales Chamorro; Gricell Jeraldina Báez Arévalo.

23reconstructed exposure schedules
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Methods

Retrospective systematic review of a curated corpus and a metascientific audit using 28 exploratory FDRI-28 items.

Scope and limitations

Percentages describe the selected corpus under the exploratory instrument. The audit characterizes documentation; it does not replace source calibration or estimate prevalence across the literature.

Published findings

The audit analyzed 84 reports and 2,352 decisions. Mean reporting completeness was 45.72%; radiometry and calibration was the least complete domain (15.67%). Two reports met the combined basic-reporting criterion and none met the traceability criterion. Of 23 evaluable schedules, 21 agreed arithmetically within 5%.

Environmental evaluation in Chilee0004 · Vol. 1 · 2026

Changes in surface ATP following 222-nm far-UVC irradiation: a multicentre before-and-after study in 29 healthcare facilities in Chile

Multicentre before-and-after study

Kevin Virgilio Morales Chamorro; Gricell Jeraldina Báez Arévalo.

81.3%combined ATP reduction
Explore methods and scope

Methods

Uncontrolled multicentre before-and-after study of surface ATP following environmental use of 222-nm Virgilio Rays.

Scope and limitations

ATP is an indicator of organic or biological residues. The design describes a temporal association without isolating the contribution of UV-C; it does not directly measure viable microorganisms or infection reduction.

Published findings

The study analyzed 437 paired surface readings in 29 healthcare facilities. Median ATP decreased from 199 to 50 RLU (relative light units). The combined reduction was 81.3% (95% CI 77.7–84.3%), with between-facility heterogeneity (I²=84.3%). All 437 post-cycle readings were lower than baseline.

Experimental indoor dosimetrye0005 · Vol. 1 · 2026

Semiquantitative photochromic dosimetry of UV-C exposure in classrooms, dental clinics and restrooms: an exploratory experimental study

Exploratory experimental study

Cristel Francely Miranda Lazo; Lindy Pahola Loza; Jennifer López González; and colleagues.

View all authors (34)

Cristel Francely Miranda Lazo; Lindy Pahola Loza; Jennifer López González; Elba Cristalia González; Axel Alejandro Gámez Guerrero; Pedro Josué Zepeda Espinoza; Alexa Isabella Nicaragua Casaya; Elmer Francisco Baltodano Mejia; Michelle Murillo Sánchez; Bertha Abigail Espinoza Manzanarez; Helen Viviana Cajina Balmaceda; Kristel Dariana Amador Murillo; William Morales Bermúdez; Ilfred Mercedes Reyes Jaime; Emily Isabel Vargas; Keysi Javiera Conto Baltodano; Dubraska Isabel Estrada Márquez; Javier Antonio Chávez Treminio; Jannys Marcela Betancour Urbina; Shirly María Moya Arguello; Gloria Elena Duarte Morales; Ligia Elena Ordóñez Alemán; María José Guadamúz Selva; María Mercedes Rocha Trujillo; Steyssis Guadalupe Berrios Chávez; Alejandra Massiel Dauria Vivas; José Alfonso Castillo Rosales; Franchesca Marie Tercero Sánchez; Fátima Geraldina Chorro Bermúdez; Meyling Ignacia Arley Córdoba; Kevin Alexandro Cazorla Lata; William Conrado; Silvio Alejandro Ortega Chow; Amanda Leticia Vega Fong.

14numerical readings · 8 series
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Methods

Exploratory experimental study conducted in Managua in 2022, using visually read UVCiX cards and electronic source characterization.

Scope and limitations

Readings are semiquantitative and depend on position and exposure conditions. The work characterizes physical exposure and does not evaluate microbiological efficacy or clinical outcomes.

Published findings

Fourteen numerical readings from eight series supported the dosimetric description; ten allowed comparison with nominal targets. Reading-to-target ratios ranged from 10.0% to 125.0%. For a calculated exposure of 97.2 mJ/cm² at two classroom positions, cards indicated 90–100 mJ/cm² at 1 m for 15 minutes and 50–75 mJ/cm² at 2 m for 30 minutes.

Consult the complete sources

The articles contain detailed methods, references, authorship, funding and study declarations. For product-specific technical documentation, specify the country and evaluation purpose when contacting the team.

Contact the team